Abstract
Intestinal absorption of antigenic (intact) and degraded β-lacto-globulin (β-lg) and horseradish perioxidase (HRP) was studied in rabbits experimentally infected at weaning with the rabbit-specific Escherichia coli strain RDEC-1 (015: NM). Traneptithelial fluxes of both proteins were measured at four stages post infection: early, peak, late and recovery, on segments of ileum and Peyer's patches mounted in Ussing chambers. During this period of observation, absorption of antigenic β-lg and intact HRP decreased significantly in the ileum and Peyer's patches of age-matched controls probably reflecting gut closure to the food antigen. No significant age-related decrease was observed in the controls for the transport of these proteins in degraded form. During the early phase of RDEC-1 infection, absorption of egraded protein fluxes rose across Peyer's patches only. During the peak phase of infection, absorption of antigenic β-lg (74.0 ng/h.cm2) and intact HRP (21.8 ng/h cm2) rose fivefold compared to controls (15.8 and 4.4 ng/h.cm2 respectively). These rises, which were also found in Peyer's patches, delayed the physiologic decrease in protein absorption which occurs with age. These results indicate that increased antigen absorption is observed during RDEC-1 bacterial diarrhea, and that it might interfere with the immune responses of the host.
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Isolauri, E., Heyman, M., Cotteland, M. et al. INCREASED ANTICEN ABSOBPTIN INDUCED BY INFECTION WITH THE ADHERENT ENTEROPATHOCENIC E.COLI STRAIN RDEC-1 IN RABBIT ILEUH AND PEYER'S PATCHES. Pediatr Res 26, 272 (1989). https://doi.org/10.1203/00006450-198909000-00052
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DOI: https://doi.org/10.1203/00006450-198909000-00052