Abstract
ABSTRACT: Mucin levels are generally elevated in sera from many cystic fibrosis (CF) patients as measured by radioimmunoassay using monoclonal antibody 19-9, which is directed against the mucin-associated sialyl Lea antigen. Antibody 19-9 can only be used to measure mucin-associated antigen levels in those patients who are genetically able to make detectable levels of mucin-associated sialyl Lea epitope. Serial studies of 20 patients followed over 3 - 5 y showed that their serum mucin-associated antigen levels varied directly with respect to the severity of their disease and inversely with their Shwachman-Kulczycki clinical scores (p<0.001) and Brasfield chest roentgenographic scores (p<0.02). Serum mucin-associated antigen levels in samples from 89 CF patients were generally higher in the older patients (j><0.025). Serum mucinassociated antigen levels of CF patients who were colonized with Pseudomonas aeruginosa did not significantly differ from those of uninfected CF patients. The mean serum mucin-associated antigen level of CF patients colonized with Pseudomonas was higher than the mean mucin level of six non-CF bronchiectatic patients whose lungs were colonized with Pseudomonas (p=0.053). Serum mucinassociated antigen levels are thus related to CF patients' ages and clinical statuses.
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Frates, R., Fink, R., Chernick, M. et al. Serum Mucin-Associated Antigen Levels of Cystic Fibrosis Patients Are Related to Their Ages and Clinical Statuses. Pediatr Res 25, 49–54 (1989). https://doi.org/10.1203/00006450-198901000-00013
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DOI: https://doi.org/10.1203/00006450-198901000-00013