Abstract
We have previously shown in 14 normal adult males that an 8 day continuous s.c. infusion of GHRH (1-29) in a dose regimen of 60ng/kg/min efficiently augmented GH secretion (ESPE 1987). There was no evidence of desensitization of the hypothalamo-pituitary axis over a range of doses from 7.5-120ng/kg/min.
We now report a study of treatment of 8 children with continuous GHRH infusion for six months. All were short, slowly growing prepubertal children with peak GH responses to insulin-induced hypoglycaemia of 10-20mu/l. 24 hour GH profiles were performed before treatment, on Day 1, at 5 weeks, three months and six months into treatment. GHRH (1-29) was infused continuously subcutaneously at a rate of 60ng/kg/min. Sum of GH pulse amplitudes over 24 hours rose from a baseline value of 96.6mu/l/24hrs (range 50.9-133.9) to 228.9mu/l/24hrs (range 92.4-470.3) on Day 1. This rise was highly statistically significant and did not change further with time. The increment of growth hormone secretion was accompanied by a significant increase in growth velocity from 4.4cm/year (range 3.6-5.1) to 7.6cm/year (range 4.8-11.7) (p=0.02).
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Brain, C., Hindmarsh, P., Pringle, P. et al. 94 CONTINUOUS S. C. INFUSION OF CHRH (1–29) AUGMENTS CH SECRETION AND PROMOTES GROWTH OVER SIX MONTHS. Pediatr Res 24, 532 (1988). https://doi.org/10.1203/00006450-198810000-00115
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DOI: https://doi.org/10.1203/00006450-198810000-00115