Abstract
The prognostic value of 15N-(stable isotope nitrogen)-retention (mass-spectrometry) and serum levels of fragments of type 1 collagen (bone and Interstitial fibrils) and type III procollagen (interstitial fibrils) (both by RIA) was studied in 20 hGH deficient children (median age: 10 ys). Patients showing good responses to hGH-therapy (increases above 1 SDS of height for chronological age after 1 year of treatment) had higher mean collagen levels during treatment (Type I: 214 ± 14 vs. 200 ± 14 ng/ml; Type III: 43.3 ± 13.7 vs. 39.5 ± 8.0 ng/ml) than those with smaller responses. The median increase after 3 days of hGH (21U/m2/dle) was higher in those with better responses (Type I: 22 vs. 10 ng/ml; Type III: 13.5 vs. 7.2 ng/ml). Cumulative renal 15N-excretion decreased from pretreatment median values of 0.91 to 0.54 mg/15N/kg. However. 15N-rctention (in %) was identical for good and poor hGH responders (44 %). Short-term administration (3 × 21U/m2) in patients with Turner's Syndrome (n=5) showed no median change of type III collagen (1.7 ng/ml) and 15N retention (9.2%). Therefore, longterm hGH-treatment with such doses in Turner patients are not likely to induce optimal growth responses. Furthermore, these results suggest studies of both 15N-retention test, as well as type I and type III collagen serum levels to predict the response before initiation of longterm hGH-treatment.
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Schnabel, D., Danne, T., Bröslcke, H. et al. 36 MEASUREMENT OF 15N-RETENTION AND TYPE I AND TYPE III COLLAGEN SERUM LEVELS PREDICTS RESPONSE OF TREATMENT WITH HUMAN GROWTH HORMONE (hGH). Pediatr Res 24, 523 (1988). https://doi.org/10.1203/00006450-198810000-00057
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DOI: https://doi.org/10.1203/00006450-198810000-00057