Abstract
Repeated plasma basal and glucagon stimulated C-peptide (CP) levels were determined at diagnosis, 1 mo. & 3-mos. intervals for 2 yrs in 72 newly diagnosed JDDM (38 M, 34 F)with a mean age of 12.1 ± 2.7 yrs. An analysis was performed of the correlation between basal and peak CP levels, HbA1 and daily insulin (I) dose at each period. According to basal and peak CP at 3 and 12 mos., three groups were differentiated:
The following predictive factors for future insulin needs were found: a) basal CP levels at diagnosis of 0.15 pM/ml or more (Gr. A) are predictive for a long remission; b) a ratio of peak CP/I (exogenous) of less than 0.5 at 1 month (Gr. C) indicates no chance of remission and calls for progressive increase of insulin dose.
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Laron, Z., Klipper, Y., Karp, M. et al. 10 C-PEPTIDE LEVELS IN NEWLY DIACNOSED TDDM AS AN INDICATOR FOR THE ADJUSTMENT OF THE INSULIN DOSE. Pediatr Res 24, 518 (1988). https://doi.org/10.1203/00006450-198810000-00031
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DOI: https://doi.org/10.1203/00006450-198810000-00031