Abstract
Fecal BA composition was studied in children with IBD and healthy controls, using capillary ookim gas chromafcography. The feces were collected during 72 hrs. 16 children with ulcerative colitis and 2 with Crohn's disease and colitis (age range 10-17 yrs) were compared to 5 healthy children (age range 10-17 yrs). All patients were on sulphasalazine and all except one had normal stools. The patients excreted significantly more BA than the controls, 8.43 ±0.8 (S.E:M.) mg/g dry wt feces and 3.06 ± 0.6 (S.E.M.) mg/g dry wt feces, respectively, p<0.001. The patients had significantly more primary and conjugated BA compared to controls.
BA in fecal water (FW) were also studied. The FW was prepared by centrifugation of feces at 15000 rpm for 2 hrs. The total concentraticn of BA in FW was significantly higher in patients than controls, 0.08 ± 0.02 (S.E.M.) mg/g feces and 0.02 ± 0.005 (S.E.M.) mg/g feces respectively, p<0.001. The BA composition in FW was almost the same as in total feces, with more primary (48% vs lL%) end conjugated (8.5% vs 4%) BA in patients compared to controls. The study shows markedly changed BA pattern in juvenile IBD without diarrhea.
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Ederham, J., Strandvik, B. 93 FECAL BILE ACID (BA) EXCRETION IN CHILDREN WITH INFLAMMATORYDISEASE (IBD). Pediatr Res 24, 420 (1988). https://doi.org/10.1203/00006450-198809000-00116
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DOI: https://doi.org/10.1203/00006450-198809000-00116