Abstract
Bloch and Walker (1) showed that there was enhanced uptake of an unrelated bystander protein (bovine serum albumin) from the gut when rats presensitised to ovalbumin were challenged intraducdenally with that antigen. We have recently confirmed and extended these observations (2) which may help to explain the development of multiple food protein hypersensitivities in man. In the present study we have used this animal model to investigate the modulatory action of various ahti-allergic drugs on the uptake of bystander protein and release of the mediator serine protease RMCFII which is specific to the mucosal mast cell. Four drugs were tested at a single high dose by simultaneous administration with the BSA. Of these, beclamethasone diproprionate was the most effective in reducing BSA uptake (p<0.002). Nedocromil was also active (p<0.02) but disodium cromoglycate was only marginally active. Doxantrazole, a drug known to inhibit histamine release from mucosal mast cells in vitro, was, however, inactive. In contrast, at the dcees used, none of these drugs had any effect on the release of the RMCPII enzyme. This suggests that the reduction in protein uptake from the gut observed with seme drugs is not paralleled by any inhibition of RMCPII release.
(1) Bloch KJ & walker WA (1981), J Allergy Clin Immunol 67:312.
(2) Turner MW et al (1988). Immunology (in press)
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Turner, M., Boulton, P., Levinsky, R. et al. 44 DRUG MODULATION OF INTESTINAL HYPERSENSITIVITY REACTIONS IN THE RAT. Pediatr Res 24, 412 (1988). https://doi.org/10.1203/00006450-198809000-00067
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DOI: https://doi.org/10.1203/00006450-198809000-00067