Abstract
Circulating immune complexes containing IgA have a pathogenetic role in IgAN. Dietary antigens are thought to represent a major component of immune complexes (1). Aim of this paper was to investigate the integrity of the gut mucosal barrier in children with IgAN.
Intestinal absorption and permeability were measured in 14 children with IgAN (mean age: 10.5±4.5 years), 12 coeliac patients on normal diet and 15 age-matched controls. After an oral load of 2.5 g lactulose (Lac), 0.5 g rhamnose (Rh), 2.5 g D-xylose (Xy) and 1.25 g 3-o-methylglucose (3-o-MG), plasma levels and urinary recovery were assessed by thyn layer chromatography (2).
The results indicate that abnormal gut permeability may play a role in IgAN. It remains to be established if it represents a primary defect or the result of a deranged mucosal immunity.
1) Sancho J. et al., Clin. Exp. Immunol., 1983, 54:194-202.
2) Menzies I.S. et al., Lancet 1979, 11, 1107-1109.
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Pecoraro, C., Troncone, R., Parrilli, G. et al. 42 ABNORMAL INTESTINAL PERMEABILITY IN CHILDREN WITH IGA NEPHROPATHY (IgNA). Pediatr Res 24, 412 (1988). https://doi.org/10.1203/00006450-198809000-00065
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DOI: https://doi.org/10.1203/00006450-198809000-00065