Abstract
By using a radioimmunological method (1) we have found that the intestinal absorption of the macromolecule human α-lactalbumin (LA) is increased in the immature gut and in infants with gastrointestinal disorders, as cow's milk allergy.
The aim of this study was to measure macromolecule absorption in breast fed and formula fed infants with infantile colic. All infants were born at term. Serum samples were analyzed for LA at 30 and 60 minutes after an intake of human milk. Breast fed infants with infantile colic had increased absorption of LA (mean value 510 μg LA/1 serum/1 human milk/kg body weight, n=40) compared with breast fed, control infants (mean value 64, n=15). Formula fed infants with infantile colic had higher concentrations of serum LA (mean value 230, n=24) than formula fed control infants (mean value 20, n=12).
Conclusion: Infants with infantile colic have increased absorption of macromolecules (human LA). This is most pronounced in breast fed infants. The finding might suggest that the gut mucosa in some way is affected in infantile colic.
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Lindberg, T., Lothe, L. & Jakobsson, I. 16 MACROMOLECULAR ABSORPTION IN INFANTS WITH INFANTILE COLIC. Pediatr Res 24, 407 (1988). https://doi.org/10.1203/00006450-198809000-00039
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DOI: https://doi.org/10.1203/00006450-198809000-00039