Abstract
Patients and methods: Since differences in pulmonary function in VLBW infants with RDS and congenital pneumonia (c.p.) after natural surfactant therapy not yet have been described, we analysed the data of 33 infants with RDS and 14 with c.p. C.p. was diagnosed from positive bacteriological culture of tracheal aspirate. 30-50 mg/kg birth weight (b.w.) bovine surfactant (SF-RI 1) was given intratracheally, if severe respiratory failure was diagnosed. B.W. ranged from 430-1500 g (median 770 g) in RDS-infants from 530-940 g (median 690 g) in c.p. infants. Results: Time response curves for FiO2 in RDS (solid bars) and c.p. infants (striped bars) after SF-RI 1 are depicted. Peak inspiratory and mean airway pressure showed similar differences. Conclusion: Pulmonary effects (decrease in FiO2 PIP, MAP) after SF-RI 1 are longer stabile in RDS, compared to c.p. infants.
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Gortner, L., Pohlandt, F., Bartmann, P. et al. 3 PULMONARY FUNCTION AFTER BOVINE SURFACTANT (SF-RI 1) IN VLBW INFANTS WITH RDS AND CONGENITAL PNEUMONIA. Pediatr Res 24, 261 (1988). https://doi.org/10.1203/00006450-198808000-00029
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DOI: https://doi.org/10.1203/00006450-198808000-00029