Abstract
ABSTRACT: Using a monoclonal anti-human IgE receptor (FceR) antibody, the percentage of FceR(+) cells among peripheral blood lymphocytes in children with or without allergic disorders was determined. The percentage of FctR(+) cells in 63 nonallergic children was 4.3 ± 1.5%, which did not vary with age and was equal to that of adults (4.2 ± 1.2%). Allergic younger children (0–2 yr) showed a significantly higher percentage of FceR(+) cells (7.7 ± 3.0%) than nonallergic younger children (0–2 yr) (4.0 ± 1.3%, p < 0.001). Similarly, in allergic younger children, serum IgE levels (geometric mean = 58.9 IU/ml) were also significantly higher than those of nonallergic younger children (geometric mean = 2.0 IU/ml) (p < 0.01). A positive correlation between the percentages of FccR(+) cells and serum IgE levels was observed (Spearman rank = 0.88, p < 0.01)) in eight allergic younger children (0–2 yr) with serum IgE levels higher than 100 IU/ml. The increase in the percentage of FctR(+) cells in allergic younger children (0–2 yr) was not a secondary phenomenon caused by serum IgE because serum IgE levels in these children were much lower than the concentration at which IgE enhance FceR expression on lymphocytes. In conclusion, FceR(+) lymphocytes may play a regulatory role in IgE synthesis in allergic younger children (0–2 yr).
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Kim, KM., Mayumi, M., Iwai, Y. et al. IgE Receptor-Bearing Lymphocytes in Allergic and Nonallergic Children. Pediatr Res 24, 254–257 (1988). https://doi.org/10.1203/00006450-198808000-00023
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DOI: https://doi.org/10.1203/00006450-198808000-00023