Abstract
Retarded effects of the radiotherapy to the neck and/or polychemoterapy on the thyroid were investigated in 66 patients (P), 47 with Hodgdn's disease (HD) and 19 with rcn-Hodgkin's lymphoma (NHL). Two, recently diagnosed, untreated P, were also studied. Age ranged from 6.2 to 52 years (median 13.5). Patients were divided in 3 groups: a-) 29 P treated with chemo and radiotherapy (radiation dose to the thyroid ranged from 300 to 6300r, median 3000); b-) 37 P with chemotherapy and c-) 2 P without treatment. Group a: 16 P (55%) showed an elevated basal and/or post TRH, TSH value; 7 (25%) of 28 P studied had positive antimicrosomal thyroid antibody titers (AM Ab); diagnosis of papillary carcinoma was made in 1 P. Prevalence of high TSH level was 33% within 2 years of radiotherapy and 66% after 61 months. Group b: 11 (30%) of 36 P showed elevated TSH levels; 9 (27%) of 33 P had positive AM Ab. Group c: 1 P with HD had goiter, elevated TSH levels and negative AM Ab. Sixteen (26%) of 61 P studied post-treatment had positive AM Ab. Higher frequency of high TSH levels was observed in P receiving radiotherapy (56 vs 30%). With longer intervals free of treatment, the prevalence increased. Prevalence of positive AM Ab was higher in our P than in our normal population (26 vs 4.4%). A genetic predisposition to autoimmune thyroid disease cannot be ruled out and the influence of treatment is difficult to assess.
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Pascualini, T., Iorcansky, S., Gruñeiro, L. et al. 20. THYROID DYSFUNCTION IN MALIGNANT LYMPHOMA. Pediatr Res 23, 650 (1988). https://doi.org/10.1203/00006450-198806000-00043
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DOI: https://doi.org/10.1203/00006450-198806000-00043