Abstract
ABSTRACT: Erythrocyte transketolase activity and thiamin pyrophosphate effect were examined in the offspring of streptozotocin-diabetic rats. Thiamin reserve was found to be significantly reduced in litters of untreated diabetic rats as compared to control and to insulin-treated diabetic rats. Supplementation of the untreated diabetic dams throughout pregnancy with oral thiamin was associated with a significantly improved thiamin status of the litters. We conclude that, due to enhanced fetal glucose turnover during diabetic gestation, a fetal thiamin deficiency state may evolve; this condition can be remedied with maternal thiamin supplementation.
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Berant, M., Berkovitz, D., Mandel, H. et al. Thiamin Status of the Offspring of Diabetic Rats. Pediatr Res 23, 574–575 (1988). https://doi.org/10.1203/00006450-198806000-00008
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DOI: https://doi.org/10.1203/00006450-198806000-00008