Abstract
ABSTRACT: Ventilation of immature airways has been shown to result in pressure-induced deformation and alteration of mechanical properties. These changes in mechanical properties may alter the effect of compressive pressures on pressure-flow relationships. To test this hypothesis, unventilated (Group I, n = 8) and ventilated (group II, n = 8; mean pressures of 8–12 cm H2O for 2 h duration) tracheal segments were excised from preterm lambs approximately 118 days gestation and mounted in a Krebs-filled chamber for determination of compliances and pressure-flow relationships. Compliance data were obtained for both the inflation loop (inflation compliance) and the collapsing loop (collapsing compliance) of the pressure-volume curve for each segment. Flow (V = 2–10 liter/min.) was introduced through the lumen of each segment at different chamber pressures (Pc = 5–30 mm Hg). Driving pressure (Pd) was recorded for each V and Pc. Airway resistance (R) was calculated as Pd/V. Group II had significantly greater (p < 0.005) radii than Group I, suggesting ventilation-induced deformation. Group II had significantly lower (p < 0.05) inflation compliance but significantly greater (p < 0.05) collapsing compliance than group I. Two-factor analysis of variance demonstrated significantly greater (p < 0.05) R in group II at each value of V and each Pc. These data may help to explain the flow limitation and gas-trapping observed in preterm infants who have been mechanically ventilated.
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Penn, R., Wolfson, M. & Shaffer, T. Effect of Ventilation on Mechanical Properties and Pressure-Flow Relationships of Immature Airways. Pediatr Res 23, 519–524 (1988). https://doi.org/10.1203/00006450-198805000-00017
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DOI: https://doi.org/10.1203/00006450-198805000-00017