Abstract
Numerous urinary steroids were measured before treatment in 9 children (8f, IM) with Cushing's disease: 4 patients with pituitary dependent adrenal hyperplasia (H), 1 with bilateral micronodular dysplasia (MD), 2 with adrenal adenoma (A) and 2 with adrenal carcinoma (C). Important steroids or steroid-group-excret.ions are shown in mg/24 h compared to normals (N):
The excretion of total cortisolmetabolites (ΣTHF) was increasing in the order of MD < A < H < C, THS in order of H < A < MD < C. p-triol, Δ-5-P-triol, 17KS and 16-OH-DHA were highly increased in the carcinoma patients. Distinction between malignant and benign tumor was therefore possible, whereas no distinction between adenoma and micronodular dysplasia was seen.
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Nielsen, M., Petersen, K. & Krabbe, S. URINARY STEROID PROFILE IN CHILDHOOD CUSHING'S DISEASE. Pediatr Res 23, 129 (1988). https://doi.org/10.1203/00006450-198801000-00168
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DOI: https://doi.org/10.1203/00006450-198801000-00168