Abstract
Glucose tolerance was evaluated by means of an OGTT in 16 girls with Turner's syndrome submitted to estrogen-progestogen treatment (10 subjects 45, X, 1 X-mosaic and 5 X structural abnormalities). OGTT was performed before treatment, on treatment after the first 3 months (1st control) and after various cycles of 3 months each (2nd control), and after therapy withdrawal for 3 months after last cycle. On treatment: significantly higher blood glucose values than those of pretreatment were present at the 1st control at time 90 (p < 0.01) and 180 mins (p < 0.025) and for the area (p < 0.005) and at the 2nd control at time 90 (p < 0.01 ), 120 and 180 mins. (p < 0.025) and for the area (p<0.05). Insulin values were significantly higher than those of pretreatment OGTT at time 180 (p < 0.05) for the 1st control and at time 90 (p < 0.0l) and 180 mins and for the area (p< 0.05) at the 2nd control. After suspension of treatment: Blood glucose and insulin values were lower (p < 0.05 at 180 mins) than those observed during treatment and no longer showed significant differences compared to pretreatment values. these data show estrogen-progestogen replacement therapy induces an increase in insulin requirements which however does not prevent an increase in blood glucose values. This phenomenon can be reversed after hormone replacement treatment has been suspended. In conclusion although care should be exercised when Turner's patients receive steroid replacement therapy, brief treatment withdrawal seems sufficient to induce a recovery of glucose tolerance.
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Mazzanti, L., Cicognani, A., Pellacani, A. et al. EFFECT OF ESTROGEN-PROGESTOGEN TREATMENT ON CARBOHYDRATE TOLERANCE IN TURNER'S SYNDROME. Pediatr Res 23, 127 (1988). https://doi.org/10.1203/00006450-198801000-00157
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DOI: https://doi.org/10.1203/00006450-198801000-00157