Abstract
On the basis, of recent evidences, CGD seems to be a heterogeneous disorder and it has been hypothesized that some of these children could profit from different therapies. We investigated the natural outcome of a group of never treated CGD children especially in regard to their F.H..49 children (35 males and 14 females) with CGD have been followed at least yearly since prepuberty till the end of growth (bone age > 18 yrs in f.and > 19 yrs in m.). At diagnosis height was between -1 and -3 standard deviation score (SDS)(20% of the patients < 2.5 HSDS); bone age (BA)at least < 2DS for chronological age (CA)and growth velocity in the low-normal range for CA. The most important results can be summarized as follows: -mean F.H. was reached later than in normal population (17-23 yrs CA);it is always in the normal range and well correlated with the genetic target calculated on the basis of parental height (=0.68; p < 0.001). Just in 1 case F.H.was<-2DS from the target.-Height prediction (Bayley and Pinneau) is correlated with F.H. both in prepuberty and in puberty (p < 0.005);however it overestimated in both age groups (31% of cases in orepuberty and 26% in puberty).-Puberty started at 12.k yrs in f.and 13 yrs in m.and ended 3 yrs later in both sexes.
In conclusion, our data confirm the fact that CGD (at least when prepubertal height is > -3DS) is a benign condition reaching all the patients normal height well correlated with the genetic target.
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Ghizzoni, L., Bernasconi, S., Volta, C. et al. FINAL HEIGHT (F.H.) IN A GROUP OF CHILDREN WITH CONSTITUTIONAL GROWTH DELAY (CGO). Pediatr Res 23, 125 (1988). https://doi.org/10.1203/00006450-198801000-00146
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DOI: https://doi.org/10.1203/00006450-198801000-00146