Abstract
We have shown that GHRH administered subcutaneously in a pulsatile fashion is effective in the treatment of GH deficieny. We have studied the effect of continuous 8 day s.c. in fusions of GHRH(1-29) on GH secretion in 10 normal adult male volunteers aged 19-24 years.
24 hour GH profiles were performed on day 0 and on days 1 and 8 of the infusion. Doses of GHRH were doubled progressively from 7.5 to 120ng/kg/min. Baseline profiles were within normal range for our Laboratory.
GH secretion was not augmented by doses of 7.5 and 15ng/kg/min. With 30ng/kg/min significant increases in GH pulse frequency and amplitude were achieved with normal profiles. Doses of 60 and 120ng/kg/min induced high pulse frequency (up to 13 pulses/24 h) and we know from clinical studies that GH neurosecretory dysfunction (>9 pulses/24 h) fails to produce adequate growth. 120ng/kg/min also produced very high GH peaks (max 122mU/L) which failed to return to the baseline between pulses, an abnormal pulse profile.
There has been no evidence of desensitization of the hypothalamo-pituitary axis at any dose over one week. The profiles indicate that a promising therapeutic regimen might be achieved by the continuous administration of GHRH1-29.
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Brain, C., Brook, C. CONTINUOUS S. C. INFUSIONS OF GHRH ANALOGUE GHRH (1–29) DO NOT DESENSITIZE THE SOMATOTROPH. Pediatr Res 23, 121 (1988). https://doi.org/10.1203/00006450-198801000-00121
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DOI: https://doi.org/10.1203/00006450-198801000-00121