Abstract
The purposes of this retrospective study of the 26 patients (17 male (67%), 9 female (35%); mean age SD = 2.8 2 years) treated for Kawasaki syndrome at our centre since 1977 were to describe their clinical and laboratory presentation, and to evaluate high-risk factors for the development of coronary arterial complications and effects of different therapies in preventing the coronary involvement. The diagnostic critieria were met by 100% for fever and rash, by 96% for digital desquamation, by 92% for bilateral conjunctival injection and mucous membrane changes, by 81% for cervical lymphadenopathy, and by 54% for peripheral edema/erythema. Treatment included aspirin, in the beginning also antibiotics, and since 1986 high-dose intravenous Immune globulins (IVIG). Regular routine electrocardiogram and echocardiogram controls recorded 9 cardiovascular complications: 6x carditis (23%) and 3x coronary artery aneurysm (12%). The 3 patients with coronary aneurysm were all oales, and compared to the others both younger (22 vs. 33 mths) and febrile over a longer period of time (22 vs 12 dys); elevated acute-phase reactants such as ESR, leukocyte and platelet counts were similar in both groups and did not affect prognosis. Since the therapeutic use of IVIG no more cardiac complications were detected. All patients are clinically cured. The findings of carditis in 6 and of coronary aneurysm in 2 patients completely resolved; one patient with regressive coronary aneurysm shows myopathic cardiomegaly after 2 yrs.
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Schaad, U., Odermatt, K., Weber, J. et al. 6. KAWASAKI SYNDROME IN BERNE, SWITZERLAND, 1977–1986; REVIEW OF 26 PATIENTS. Pediatr Res 24, 654 (1988). https://doi.org/10.1203/00006450-198811000-00028
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DOI: https://doi.org/10.1203/00006450-198811000-00028