Abstract
17 children with AIDS, ARC and other manifestations of HIV infection as well as asymptomatic ones were vaccinated with pneumococcal polysaccaride vaccine. Antibody to 12/23 types represented in the vaccine was tested a month later. Only 2/17 subjects responded to types 6A, 9N and 14 - poor antigens in normal subjects - whereas 6 to 13/17 subjects showed good response (>40% of baseline value or over 200 nanograms antibody N/ml) to types 1, 3, 7F, 8, 12F, 18, 19F, 23F and 4. The antibody production was not related to the classification of HIV infection status. Patients with AIDS, ARC, as well as asymptomatic ones showed similar degree of responses. Two patients that showed no response to 12 pneumococcal types were classified as ARC. Results indicate that HIV infected children can respond to B cell antigens even though protection provided by the pneumococcal vaccine may be limited.
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Fikrig, S., Menez-Bautista, R., Menikoff, H. et al. RESPONSE OF HIV INFECTED CHILDREN TO PNEUMOCOCCAL VACCINE. Pediatr Res 21 (Suppl 4), 311 (1987). https://doi.org/10.1203/00006450-198704010-00864
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DOI: https://doi.org/10.1203/00006450-198704010-00864
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