Abstract
The elevated serum gastrin of the neonate may be the result of maximum stimulation of the G-cell. Epinephrine is a stimulant of gastrin release in adult man. This study evaluated the effects of epinephrine on basal serum gastrin in neonatal pigs. Thirteen Landrace piglets less than fourteen days of age were administered halothane, nitrous oxide, oxygen mixture. After a 15 minute period, IV epinephrine was administered at 25 or 50ng/kg/min for 15 minutes. After a second 30 min stablization, epinephrine was administered at 100 or 200ng/kg/min. Blood samples for gastrin and epinephrine were obtained at 5, 10, and 15 minutes of infusion. Samples were assayed for gastrin by radioimmunoassay and epinephrine by high performance liquid chromatography.
1) Epinephrine in doses of 25 and 50 ng/kg/min result in a significant decrease in serum gastrin levels. Doses of 100 and 200ng/kg/min had no effect on basal gastrin levels. 2) Neonatal gastrin levels appear maximal and the G-cell cannot be stimulated by epinephrine.
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Stevens, W., Rodgers, B. EFFECT OF EPINEPHRINE ON BASAL GASTRIN LEVELS OF NEONATAL PIGS. Pediatr Res 21 (Suppl 4), 278 (1987). https://doi.org/10.1203/00006450-198704010-00665
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DOI: https://doi.org/10.1203/00006450-198704010-00665