Abstract
Previous studies concentrating on single or only few immune functions of patients with inflammatory bowel disease (IBD) have reported conflicting results. The aim of our study was to perform an extensive analysis of the immune system of IBD patients and compare it with normal controls. The study group included: 16 patients with ulcerative colitis (UC), ages 15-42 years (mean 30), 14 with Crohn's disease (CD), ages 10-42 years (mean 22), and 15 healthy individuals ages 9-40 years (mean 29) serving as controls. The IBD patients were categorized as active or nonactive and the treatment was recorded. The specific immunological work-up included: lymphoblast transformation in the presence of CON-A, PHA and pokweed mitogen; T-cells and subgroups of helper and suppressor cells; B and NK cell count; Immunoglobulins C3 and C4; Interleukin 2 and NBT test. In addition, each subject underwent five skin tests using mumps, Candida, and tuberculin antigens, streptokinase, and saline as control. The results demonstrated in general, a normal immune function in the IBD patients, compared with the controls. Activity of the disease and treatment had no significant effect on the immune function. The statistical analysis of the 44 recorded variables resulted in the following conclusions: 1) CD patients are distinguished from controls by low Hb, total protein, albumin, IgA, and high ESR, platelet count, C3 and C4; 2) UC patients are distinguished by low globulin, C3 and C3; 3) The main difference between CD and UC were low albumin and high C4.
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Bujanover, Y., Hauser, G., Zakut, V. et al. A MULTIVARIANT ANALYSIS OF THE IMMUNE FUNCTIONS IN CHILDREN AND YOUNG ADULTS WITH IBD. Pediatr Res 21 (Suppl 4), 265 (1987). https://doi.org/10.1203/00006450-198704010-00586
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DOI: https://doi.org/10.1203/00006450-198704010-00586