Abstract
Incorporation of 3H-choline into 3H-SPC by slices of whole fetal rat lung is lower in males than in females at 20 days gestation (day 0= mating) (Torday and Dow, 1982), leading to the hypothesis that androgens delay fetal rat lung T II maturation. A marker for T II maturation, de novo synthesis of SPC by purified T IIs, is observed to more than double between days 19 and 21 in the developing fetal rat lung. The rate of increase has been observed to be equal in males and females, but the onset of tins increase is delayed in males, such that incorporation of 3H-choline into SPC is 30% less in males on day 20 and 21, though not different on day 19. To test the hypothesis that exogenous androgens delay T II maturation, time-mated Sprague- Dawley rats were injected with 1 mgAg of dihydrotestosterone (DHT) daily from day 14 to sacrifice. Purified T IIs from DHT-treated animals showed decreased 3H-choline incorporation into 3H-SPC, and lower SPC par T II.
These data suggest endogenous and exogenous androgens delay the onset of fetal rat lung type II cell maturation in vivo. Supported by NIH SCOR HL34616, and a Canadian Lung Assoc. Fellowship.
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Sweezey, N., Tordav, J. ALVEOLAR TYPE II CELL (TII) SYNTHESIS OF SATURATED PHOSPHATIDYLCHOLINE (SPC) IS DELAYED BY ENDOGENOUS AND EXOGENOUS ANDROGENS IN THE FETAL RAT IN VIVO. Pediatr Res 21 (Suppl 4), 222 (1987). https://doi.org/10.1203/00006450-198704010-00337
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DOI: https://doi.org/10.1203/00006450-198704010-00337