Abstract
Insults to the central nervous system (CNS) are frequently associated with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). There are few reports of serum vasopressin (VP) values in meningitis but none in head trauma (HT) in pediatric patients. We measured urine VP by RIA, urine (U) and serum (S) osmolality (Osm) and sodium in 18 nonhypoxic pediatric patients with CNS insults within 2H hours of hospitalization and daily x2. 7 patients experienced HT, 7 bacterial meningitis (BM), and 4 aseptic meningitis (AS). Mean (± SEM) urine VP (pg/ ml) results were as follows:
Pediatric patients with CNS insults demonstrated elevated urine AVP levels. Defining SIAD1I as (S)Na<135, (U)No>25, S(Osm)< 280, S(Osm)<U(Osm), 43% of HT patients, 29% of BM and none of AS exhibited the syndrome sometime during the 3 hospital days. Conclusions: 1) the prevalence of SIADH is high in HT and BM but not in AS, 2) urine VP is a reliable indicator of SIADH in hyponatremic patients.
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Padilla, G., Leake, J., Castro, R. et al. URINARY VASOPRESSIN IN CENTRAL NERVOUS SYSTEM INSULTS. Pediatr Res 21 (Suppl 4), 205 (1987). https://doi.org/10.1203/00006450-198704010-00235
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DOI: https://doi.org/10.1203/00006450-198704010-00235