Abstract
Previous reports have suggested that patients with polycythemia secondary to congenital heart disease have elevated serum erythro-poietin titers (EPO). To further define the predictors of EPO in these patients, we measured hemoglobin concentrations (Hb), PaO2, aortic oxygen saturation (SAT O2), iron storage variables, red cell 2,3-DPG, and serum EPO in 17 children less than 8 years of age with SAT O2 < 90%. Patients were divided into 2 groups, those with increased EPO ( > 30 mμ/ml ) and normal EPO. Results are shown in the table. Two patients were iron deficient and both had increased EPO. For children under 8 yrs of age, elevated EPO titers were associated with severe hypoxemia and elevated red cell 2,3-DPG. However, we found children with moderate hypoxemia and iron sufficiency to have normal EPO titers at Hb levels below those which caused significant hyperviscosity.
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Gidding, S., Stockman, J. & Goldwasser, E. ERYTHROPOIETIN TITERS IN CHILDREN WITH CYANOTIC CONGENITAL HEART DISEASE. Pediatr Res 21 (Suppl 4), 190 (1987). https://doi.org/10.1203/00006450-198704010-00142
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DOI: https://doi.org/10.1203/00006450-198704010-00142