Abstract
The amount and quality of structured fiber in the diet modifies the absorption of nutrients. However, little is known about its effect on the absorption of drugs. The effect on bioavailability and pharmacokinetics of AMX of two isocaloric and i sonitrogenous diets, one providing 7.8g xday (Diet I) and the other 36g xday (Diet II) of structured fiber, was evaluated. Ten volunteers, aged 18-32 years, apparently healthy and of the low socio-economic stratum, received one of tiie two diets, randomly selected, for 3 days and then ingested 1 capsule AMX (500 mg) after breakfast. The other diet was then administered lor additional 3 days and the procedure and measurements were repeated. Plasma and urinary AMX concentration were measured for 9 and 24 hours respectively, following a microbiological technique. A one compartment model was used for pharmacokinetic analysis. AMX was absorlxxl more slowly wtien ingested with Diet I than Diet II: ka 1.04 ± 0.37 and 1.75 ± 0.75 (p < 0.05); t1/2 was 0.72 ± 0.19 hours and 0.47 ± 0.21 hours (P<0.01); and tc was 0.34 ± 0.13 hours and 0.29 ± 0.11 hours (p<0.05), respectively. Bioavailability was higher when the drug was ingested with Diet I: area under the curve was 12.17 ± 3.04 vs 9.65 ± 2.64 ug/mL/hour witli Diet 11 (p<0.05). Urinary recovery was 41.1 ± 6.5% and 38.4 ± 14.6% with diets I and II respectively (p < 0.001). A higher content of fiber in the diet increased AMX absorption rate and decreased the amount of drug absorbed. Further investigation is needed to clarify tJie effect of fiber on doses aiid freqency of administration. It may be necessary to modify the reconmended dosage for individuals who ingest large amounts of dietary fiber.
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Espinoza, J., Lutz, M., Arancibia, A. et al. EFFECT OF DIETARY FIBER ON ABSORPTION OF AMOXICILLIN (AMX). Pediatr Res 22, 369 (1987). https://doi.org/10.1203/00006450-198709000-00031
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DOI: https://doi.org/10.1203/00006450-198709000-00031