Abstract
All live and still-born newborhs were registered in five regions of Southern Poland. A population of 33120 newborns was ascertained. This group constitutes of 54 infants with Down's syndrome, giving the birth prevalence, of 1.63/1000. The occurence risk depended neither on pregnancy order nor paternal age, both standardized for maternal age. The latter standardized for pregnancy order significantly influenced the risk of Down's syndrome(X12=37.6 p<0.0005). The distribution of incidence and relative risk of Down's syndrome depending on maternal age revealed the “J” shaped pattern, beign highest beyond the age 45 (53/1000 and RR=42.25). No association between the prevalence of Down's syndrome and parental occupation was found. Also the distribution of~probands birthdates revealed no significant seasonal trend. Highest standardized incidence of the disease /2.6/1000/ was observed for the Oświȩcim region a typically industrial area. The relative risk of bearing a child with Down's syndrome in this region in comparison to the remaining population was RR=1.9 (X12=5.03).
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Pietryzyk, J., Majerska, B. Epidemiology of Down's syndrome in Southern Poland. Pediatr Res 22, 238 (1987). https://doi.org/10.1203/00006450-198708000-00151
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DOI: https://doi.org/10.1203/00006450-198708000-00151