Abstract
There are recent contradictory reports, whether lipids, lipoproteins and apoproteins are slightly different in the children of fathers who had suffered from a myocardial infarction compared to control subjects. Therefore we studied lipids, lipoproteins and apolipoproteins (A I, A II and B) in 56 children and adolescents and their fathers (n=40, mean age 44.6±7 years) who had a myocardial infarction within the last 6 montns.
Using the percentiles of lipoprotein-lipids of the Lipid Research Clinics Study, 16 of the 56 (=28,5 %) children had had values higher than the 90th (Chol., TG, LDL-C) or lower than the 10th percentile (HDL-C). Mean apolipoprotein concentrations however, did not differ significantly from those of control subjects. This fact emphasizes the importance of screening procedures for lipoprotein abnormalities in affected family members.
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Widhalm, K., Wiedermann, U., Fridrich, L. et al. Lipids and lipoproteins in children of male patients who had a myocardial infarction. Pediatr Res 22, 236 (1987). https://doi.org/10.1203/00006450-198708000-00140
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DOI: https://doi.org/10.1203/00006450-198708000-00140