Abstract
37 of 611 patients with Crohn's disease (CD) had epitheloid granulomas without fulfilling the radiological criteria (ECCDS) of the disease. Follow-up of these patients included clinical, biochemical, radiological, endoscopic and histological investigations.
All patients showed clinical symptoms (diarrhea, abdominal pain, growth retardation) and 29 had biochemical signs of chronic inflammation. They were all treated. After a follow-up of 3 years (1;1 - 9;7 years) barium contrast roentgenograms of the upper gastrointestinal tract and of the large bowel were performed in till and in 6 children respectively. Endoscopy was done in 22 of the 37 patients.
X-ray examination revealed CD (ECCDS) in 11 children and endoscopy in 12 further cases.One patient was proven to have chronic granulomatous disease and 13 remained unclear.
Our study demonstrates that epitheloid granulomas are not always conclusive for CD. We consider the radiological criteria (ECCDS) to be too restrictive for the diagnosis of CD in children.
Supported by Volkswagen Foundation, Hannover, FRG
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Keller, K., Kirchmann, H., Ball, F. et al. 82. FOLLOW-UP OF CHILDREN WITH EPITHELOID GRANULOMAS BUT AN X-RAY PATTERN INCONCLUSIVE FOR CROHN'S DISEASE. Pediatr Res 22, 109 (1987). https://doi.org/10.1203/00006450-198707000-00103
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DOI: https://doi.org/10.1203/00006450-198707000-00103