Abstract
It is not easy to interpret the behaviour of the parathyroid hormone (PTH) in the first days of life, due to the heterogeneity of the circulating forms. 30 newborns hospitalized for minimal pathology and 20 adults as controls were studied. A small blood sample was drawn from cord and at 1,2,3,4 days of life for determination of immunoreactive COOH-terminal, middle molecule (MM) and NH2-terminal PTH and for determination of MM TPH after reversed phase chromatography. Total immunoreactivity recovered was 75% for adults and only 45% for newboms. Both MM (cord 84.73 ± 39.5 pg/ml) or COOH-terminal (cord 1.9 ± 0.93 mU/ml) showed a significant increase on the 1st day of life (265.31±184.3; 2.88±1.12 respectively); NH2-terminal (cord 17.96±4.36 pg/ml) only in the 2nd day (23.45±6.75).
The significance was always p<0.001. After reversed phase chrcmatography a significant (p<0.02) increase of MM PTH (cord 29.2±10.27) was observed only in the 3rd day of life (82.10±3.35 pg/ml). Our results testify that the percentage of immno-reactivity reversed is different in the newborns and in the adults, and that time of increase of MM PTH after reversed phase of chromatography in the newborns is different. In conclusion we suggest that the molecular structure of iPTH may be different in the newboms and adults.
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Tatò, L., Dall'Agnola, A., Tamanini, A. et al. PURIFIED PARATHYROID HORMONE IN THE FIRST DAYS OF LIFE. Pediatr Res 20, 1207 (1986). https://doi.org/10.1203/00006450-198611000-00205
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DOI: https://doi.org/10.1203/00006450-198611000-00205