Abstract
It is assumed that idiopathic central precocious puberty in girls is progressive and leads to sexual maturity. Its natural course, however, is not well defined. Four girls presented with breast enlargement (B3) at age 4.0-6.0 yrs and have been followed for up to 3.5 yrs. All had normal CT brain scans. Stimulation of LH and FSH by LHRH was excessive for age in all. Estradiol (E2) was 62-122 pmol/L. Bone age was advanced by 1.8 and 2.8 yrs in 2 girls and progressed rapidly in all. Ultrasound visualized follicular ovarian cysts in 3/4. In 2 girls, E2 fell slowly to levels around 40 pmol/L and breast enlargement decreased 1.0 to 1.5 yr after the initial work-up. The other 2 girls showed a regression of clinical signs with normalization of E2 levels after 6 and 10 months, respectively. Another 6 months later, puberty was progressing clinically and biochemically in both. As illustrated, central precocious puberty can be transient and regressing, or fluctuating in its course. This has to be considered when new drugs to control precocious puberty are evaluated for their effectiveness.
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Schwarz, H., Zuppinger, K. UNSUSTAINED CENTRAL SEXUAL PRECOCITY IN GIRLS. Pediatr Res 20, 1198 (1986). https://doi.org/10.1203/00006450-198611000-00148
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DOI: https://doi.org/10.1203/00006450-198611000-00148