Abstract
In a long-term study 66 boys with CGR and psychosocial problems were treated with low doses of 4-chlor-dehydro-methyl-testosterone (0,1 mg per kg body weight for 8 weeks, intervals of 4 weeks) for 2,7 ± 1,3 years and followed up to the 20th year of life. A control group without such treatment included 26 boys.
Results:
1. Skeletal maturity at the beginning of therapy and difference of final and predicted body height show a negative correlation. If therapy starts at bone age of less than 10 years the predicted height will not be reached (- 6,1 ± 7,3 cm). On the contrary predicted height is not diminished when treatment with anabolics starts when the bone age is 10 years or more (- 0,5 ± 3,3 cm).
2. Matched pairs of 19 treated boys with an identical control group (bone age of 10 years or more at beginning of the therapy) revealed no difference of the predicted and final body height at the age of 20 years.
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Hinkel, G., Arand, J. INFLUENCE OF LOW DOSES OF ANABOLICS ON GROWTH, DEVELOPMENT AND PERFORMANCE OF CHILDREN AND YOUTH WITH CONSTITUTIONAL GROWTH RETARDATION (CGR). Pediatr Res 20, 1197 (1986). https://doi.org/10.1203/00006450-198611000-00140
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DOI: https://doi.org/10.1203/00006450-198611000-00140