Abstract
IGF I and IGF II were measured in serum samples collected from the umbilical cord in healthy foetuses (in utero) and newborns. Results (mean tSE) were as follows :
In foetuses, IGF I levels were similar to those in cases of total GH deficiency. IGF II levels were on average 6.5 times those of IGF I. No correlation was seen between IGF levels and growth parameters estimated by ultrasounds. Western blot analysis of IGF-BPs showed that foetal serum contained smaller quantities than normal adult serum of 42 and 39 K MW forms (which in the adult appear chiefly in the ~ 150 K [IGF-BP] complex) and large quantities of the 34 and 30 K forms, which have a selective affinity for IGF II and are minor forms in adults. Such a pattern occurs in GH deficiency. Conclusion : The profile of IGFs and IGF-BPs in foetal serum is similar to that seen after birth when GH control is absent.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lassarre, C., Hardouin, S., Daffos, F. et al. INSULIN-LIKE GROWTH FACTORS AND THEIR BINDING PROTEINS (IGF-BP) IN HUMAN FOETAL SERUM. Pediatr Res 20, 1192 (1986). https://doi.org/10.1203/00006450-198611000-00113
Issue Date:
DOI: https://doi.org/10.1203/00006450-198611000-00113