Abstract
After cranial irradiation for acute lymphoblastic leukemia(ALL) low GH response to pharmacological stimulation and/or during sleep has been considered as evidence of neurosecretory dysfunction. In order to further evaluate this condition, the GH response to hpGRF 1-44 (2 μg/kg IV) was studied in 19 prepubertal children irradiated at a mean CA of 4 10/12 ± 8/12 yr (m ± sem) with 2400 rad (12×200 rad/16 days). They were evaluated after a mean interval time of 4 8/12 ± 3/12 yr and compared to an age matched group with constitutional short stature (CSS).
After irradiation the individual CH responses to GRF, although not correlated with the GH-AITT peak or SmC levels, were decreased in 17/19 cases. Furthermore in 4 cases with normal growth rates and GH-AITT peaks (9-22 ng/ml) a decreased response to GRF (12-19 ng/ml) was observed. These results suggest that an impaired GH response to GRF : 1) is a frequent finding after cranial irradiation in ALL; 2) and may be the only sign of GH neurosecretory dysfunction.
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Crosnier, H., Brauner, R., Prévot, C. et al. GH RESPONSE TO hGRF AS A SENSITIVE INDEX OF GH NEUROSECRETORY DYSFUNCTION AFTER CRANIAL IRRADIATION. Pediatr Res 20, 1189 (1986). https://doi.org/10.1203/00006450-198611000-00096
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DOI: https://doi.org/10.1203/00006450-198611000-00096