Abstract
In 38 short children we fallowed the endogenous GH-secretion for 24 h (sampling intervals of 20 min). This was immediately followed by an i v inj. of 1ug/kg of GRH 1-29. GH was estimated every 15min the following two hours. The aim was to study if the spontaneous GH-secretion, measured during the 24-h-period, had any relation to or influenced on the GH-release induced by GRH.
Patients: The chron. age of the children ranged 3-13y. 32 were prc-pubertal and 7 showed signs of eariy puberty. 6 children hod a GH-response to insulin-arginine test below 14mU/l (classically GH-def). All children were otherwise considered healthy.
Results: In 32 children the 24-h-GH-secretion varied between 54-1588 mU AUC(Area Under the Curve) over basal and with a mean of 4.1-26mU/l. The GH-def. children showed a diminshed 24-h-GH-secretion. An increased GH-secretion after GRH was found in all but one of the 38 children. Max. level of 107 ± 14mU/l, range 17-296mU/l. A high endogenous 24-h-GH secretion after GRH when estimated either as AUC over basal(r=0.47;p<0.01 ) or as mean of the 24-h-period(r:: 0.4B;p<0.01 ). The endogenous GH-secretion measured during 3h before CRH inj. did not influence on the GH-response to GRH. However, very few of the children had endogenous secretion during these morning h.
Conclusions: The correlation between a high endogenous 24-h-GH-secretion and a high GH-response to GRH, indicates that the GRH test may be a useful tool to estimate the ability to release GH in short children.
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Gelander, L., Albertsson-Wikland, K. GROWTH HORMONE (GH) RELEASE AFTER GROWTH HORMONE RELEASING HORMONE (GRH) CORRELATES TO ENDOGENOUS 24-H-GH SECRETION IN 38 SHORT CHILDREN. Pediatr Res 20, 1189 (1986). https://doi.org/10.1203/00006450-198611000-00094
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DOI: https://doi.org/10.1203/00006450-198611000-00094
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