Abstract
Early dietary manipulations may have long-lasting effects on steroid metabolism. Therefore we studied the effects of dietary fats on hepatic steroid metabolism in 4-5 weeks old rats and in adult rats on lab.chow with 20%(w/w) sunflowerseed oil(SO) or hydrogenated coconut oil (CO). After 4 weeks of diet, biliary excretion of steroids, glycine/taurine ratios(G/T) of bile acids, serum-cholesterol(C) and plasma amino acids were measured.
Serum-C in young rats on SO and CO were 2.14±0.2 and 2.54±0.2mmol/l, respectively, (significantly different p<0.05). This was opposite to the changes in biliary-C excretion.
We speculate that the low biliary-C excretion in young CO rats is related to the high G/T in biliary bile acids.
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Temmerman, A., Vonk, R., Niezen-Koning, K. et al. 176 AGE RELATED DIFFERENCES IN EFFECT OF DIETARY FATS ON STEROID METABOLISM IN RATS. Pediatr Res 20, 1063 (1986). https://doi.org/10.1203/00006450-198610000-00231
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DOI: https://doi.org/10.1203/00006450-198610000-00231