Abstract
Dumping syndrome (DS) is rare in children, but may occur after any form of gastric surgery. It is essentially characterized by symptoms of glucose intolerance and carbohydrate malabsorption. Guar and pectine are advocated for DS treatment in adults but are not suitable for use in children. Aim of our study was to define DS in terms of blood glucose (BG) and breath hydrogen (BH) changes after a glucose load, and to investigate the effect of glucomannan (GM), a new fibre, on glucose tolerance and absorption. Methods. Eight DS patients, ages 3-16 years, were subjected to glucose loads (2g /kg) without and with addition of 1% GM. The latter was stirred for 15 min in one test and swallowed directly in the other. Controls were 12 healthy children. Results. Maximum BG decrease (=difference between highest and subsequent lowest BG; mean±SD) after glucose was 2.5±1.1mM in the controls and 10.2±3.4mM in DS (p<.001). 7/8 DS patients had BH increases >10ppm (mean 54ppm). Addition of 1% GM to the glucose solution led to smaller BG decreases: 6.0±1.7 mM, p<.005 (stirred for 15 min), and 7.6±4.0mM, p<.05 (swallowed directly). BH increases did not change significantly (mean, 32 and 42ppm, resp). Conclusions: 1) DS is well defined by a maximum BG decrease >5.8mM(=mean+3SD) and a BH increase >10ppm after a glucose load; 2) 1% GM added to the glucose solution improves glucose tolerance, but has no effect on glucose absorption.
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Kneepkens, C., Vonk, R. & Fernandes, J. 175 DUMPING SYNDROME IN CHILDREN: IMPROVEMENT OF GLUCOSE TOLERANCE BY GLUCOMANNAN. Pediatr Res 20, 1063 (1986). https://doi.org/10.1203/00006450-198610000-00230
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DOI: https://doi.org/10.1203/00006450-198610000-00230