Abstract
In order to study the rapid changes in the lipid transport system of the newborn, we determined apolipoprotein (apo) A-I, A-II and B (electroimmunoassay) and cholesterol (C) daily from day 1-5 in capillary serum of 15 healthy term neviorns. Additionally, we investigated the pattern of apoA-I isoproteins, arising from proteolytic cleavage of proapoA-I to mature isoforms in plasma, and the occurrence of apoA-IV (an apolipoprotein of exclusively intestinal origin) by isoelectric focusing. Results (X±sd, mg/dl):
ApoB and C increased significantly from day 2-3 and from day 3-4 (p≤0,001). The reason for the steep increase of apoBandC during the first days remains unclear. It may be related to the onset of feeding, to hormonal factors or to a decreasing number of hepatic apo B/E receptors. Serum apoA-I was significantly higher at days 4 and 5 than at day 1 (p≤0,001). The isoprotein pattern of apoA-I determined at birth and on day 5 appeared identical to that in adults, suggesting a similar metabolism of apo A-I in both age groups. The presence of apoA-IV in cord serum could be established, which indicates a contribution of the intestine to lipoprotein biosynthesis before the onset of enteral nutrition.
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Strobl, W., Widhalm, K. & Pollak, A. 100 APOLIPOPKOTEINS A-I, A-II, A-IV, B AND APOUPOPPOTEIN A-I ISOPBOTEDJS IN NEWBOHNS. Pediatr Res 20, 1050 (1986). https://doi.org/10.1203/00006450-198610000-00155
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DOI: https://doi.org/10.1203/00006450-198610000-00155