Abstract
Treatment results of osteosarcoma improved significantly with systemic chemotherapy. Local tumor response could be higher with regional chemotherapy. This study was designed to investigate the role of isolated regional perfuslon (IRP) with cisplatin In the (local) treatment of osteosarcoma in the extremities (in dogs). Cisplatin is active for osteosarcoma and IRP prevents general toxicity. In a feasibility study using mongrel dogs (n=10) our standardized technique of IRP was used with cisplatin. Toxicity studies revealed that the highest possible dosage of cisplatin is 30 mg/liter extremity volume. Plasma levels are 10-20 fold higher compared to systemic application. Dogs from veterinary practice with extremity osteosarcoma were used to evaluate tumor response after IRP with cisplatin. Parameters: Clinical - Radiological - Histological. Seven dogs underwent perfusion, two died immediately after perfusion. Evaluable dogs (n=5) demonstrated a marked clinical improvement and good response on X-rays. Histologically responses were graded 2-4 according to Huvos, after a single perfuslon with cisplatin (biopsy: 2 and 6 weeks after perfusion). Follow-up: 1-11 months. One dog had a relapse 4 months after perfusion.
It is concluded that IRP with cisplatin can be very effective in the (temporary) local control of extremity osteosarcoma (in dogs). This kind of regional preoperatlve chemotherapy can be a contribution to limb salvage. Further study alms for optimal conditions of perfusion and evaluation of platin analogs.
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De Vries, J., Schraffordt, K., Oosterhuls, J. et al. 71 ISOLATED REGIONAL PERFUSION USING CISPLATIN IN THE TREATMENT OF OSTEOSARCOMA OF THE EXTREMITIES (IN DOGS). Pediatr Res 20, 1045 (1986). https://doi.org/10.1203/00006450-198610000-00125
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DOI: https://doi.org/10.1203/00006450-198610000-00125