Abstract
The specific activities of small intestinal brush border enzymes (lactase (L), sucrase (S), maltase (M)) were measured in pooled crypt and villous enterocytes from upper small intestines of infant mice during the course of rotavirus infection. Activities were assayed in 3 pools of enterocytes, each from 3 mice, at 72 and 96 h post infection. Infant mice were infected by oral challenge on the 7th day of life.
S and M activities rose at 96h post-infection; this was 5 days earlier than the expected rise in these enzyme activities. Thus rotavirus infection induced precocious maturation of S and M. The [concept that villi become populated with crypt-like enterocytes is therefore less tenable in the infant mouse, since S and M marker enzymes of mature enterocytes.
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Collins, J., Starkey, W., Osborne, M. et al. ACCELERATED APPEARANCE OF SUCRASE & MALTASE ACTIVITIES IN SMALL INTESTINES OF INFANT MICE INFECTED WITH ROTA VIRUS. Pediatr Res 20, 702 (1986). https://doi.org/10.1203/00006450-198607000-00100
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DOI: https://doi.org/10.1203/00006450-198607000-00100