Abstract
A follow up study was carried out of the reproductive experience of 62 couples who had been evaluated earlier at our Genetic Center because of a history of pregnancy wastage (i.e. 2 or more spontaneous abortions (SA)) and no liveborn children. Of 57 couples who had normal peripheral blood chromosome findings, 45 (79%) had subsequent normal liveborn m-fants, although 14 also had one or more additional SA. In a comparison of couples with 2 (n=29) or 3 or more (n=28) previous SA, the latter had a less favorable outlook for a liveborn infant (93.1% vs 64.3% p < 0.02) and also a greater likelihood of no further pregnancies(6.9% vs 25.0% p=n.s.). Among 5 couples with an abnormal karyotype in one member of the pair, only 1 had a normal liveborn child, 1 had an additional SA, and 2 had no recognizable pregnancies despite attempts at conception. Thus, there is a high expectation of favorable pregnancy outcome after 2 SA and a less favorable pregnancy outlook with 3 or more SA among couples with normal karyotype and no previous live births. The reproductive outlook appears to be poor in couples with a structural chromosome rearrangement.
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Hahm, S., Chltayat, D., Sachs, G. et al. 825 REPRODUCTIVE OUTCOME IN COUPLES WITH PREVIOUS PREGNANCY WASTAGE. Pediatr Res 19, 248 (1985). https://doi.org/10.1203/00006450-198504000-00855
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DOI: https://doi.org/10.1203/00006450-198504000-00855