Abstract
From 1979-1984 we evaluated 7 patients <28 mos. old because of an isolated elevation of serum alkaline phosphatase activity. Biochemical studies and, in some patients, further investigations including bone marrow aspiration, jejunal biopsy, skeletal survey, radionuclide and CT scans, UGI series, and IVP provided no explanation for the elevated SAP. Mean duration of the hyper-phosphatasemia was 6.7 weeks (range 2-10 weeks). Presenting signs and symptoms gradually resolved.
A fruitless diagnostic evaluation triggered in response to an abnormal test result inadvertently generated by automated screening has been called the Ulysses syndrome. Recognition that isolated hyperphosphatasemia in infants and young children may be transient and benign will avoid the potential risks and expense of additional testing and may ease parental anxiety.
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Schmidt, D., Rosenblum, J., Rothbaum, R. et al. 728 TRANSIENT ISOLATED HYPERPHOSPHATASEMIA: A VARIANT OF THE ULYSSES SYNDROME. Pediatr Res 19, 232 (1985). https://doi.org/10.1203/00006450-198504000-00758
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DOI: https://doi.org/10.1203/00006450-198504000-00758