Abstract
We have reported that the serum concentration of vit D2 contributes significantly to total vit D status of pregnant women at term and that fetomaternal vit D status at term is intimately related. Therefore, to determine the accuracy of predicting fetal vit D status from a history of maternal vit D intake, we elected to determine the correlation between maternal dietary vit D intake and fetomaternal 25OH vit D2/D3 status at term. Pregnancy diet histories were obtained within 48 hrs following uncomplicated full term deliveries from 17 women(16 black, 1 white). Daily vit D intake was determined with a computer data base using the recalled consumption of vit D containing foods and drugs. Plasma from mother-infant diads collected at delivery had 25OH vit D2/D3 extracted, chromatographed and quantitated using competitive protein binding assays. These values were then correlated with maternal vit D intake. All mother-infant diads were vit D sufficient. The correlation between the mother's recalled total D intake and either maternal or fetal 25OHD2/D3 and total 25 OHD at term was not significant with r values <.3, p=NS. This striking absence of correlation demonstrates that accepted dietary history gathering techniques are unacceptable methods of assessing maternal vit D status at term and cannot be used to anticipate fetal vit D status at delivery.
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Anderson, D., Hollis, B., Levine, B. et al. 610 MATERNAL DIETARY HISTORY AS INDEX OF FETAL VITAMIN D STATUS. Pediatr Res 19, 212 (1985). https://doi.org/10.1203/00006450-198504000-00640
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DOI: https://doi.org/10.1203/00006450-198504000-00640