Abstract
PGI2 synthesis by Krebs-perfused neonatal lamb lungs and hind limbs was quantified by RIA determination of 6-keto-PGF1α (6K). Perfusates were collected during a 10-min control period, a 5-min perfusion with 10−6M NE and three successive 10-min post-NE control periods. Results of 6K synthesis, ng/min; mean (SEM); n = 6:
There are no differences between the 5 time periods; pulmonary synthesis exceeds hind-limb synthesis throughout (p <.001, 2-way ANOVA). Results of perfusion pressures during these constant flow studies:
NE results in significant constriction in both vascular beds (p <.05); hind limb pressure exceeds pulmonary pressure (p <.001, 2-way ANOVA). Thus, unlike hypoxic pulmonary vasoconstriction, adrenergic vasoconstriction does not cause demonstrable augmentation of PGI2 synthesis in either lung or hind limb.
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Green, R., Sheridan, R., Leffler, C. et al. 371 EFFECT OF NOREPINEPHRINE (NE) ON VASCULAR PROSTACYCLIN (PGI2) SYNTHESIS IN THE KREBS-PERFUSED NEONATAL LAMB LUNG AND HIND LEG. Pediatr Res 19, 172 (1985). https://doi.org/10.1203/00006450-198504000-00401
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DOI: https://doi.org/10.1203/00006450-198504000-00401