Abstract
C-R curves to NE (1 × 10minus;8M to 1 × 10−2M) were performed in Krebs-perfused neonatal lamb lungs and hind limbs in the presence of beta-blockade and inhibition of the neuronal and extra-neuronal uptake mechanisms. Response at each NE concentration is expressed as percent of maximum response for a given vascular bed in an animal. Results of C-R curves (mean [SEM]; n = 5) are as follows:
(All pulmonary vs. femoral values significantly different, paired t-tests.) When response is expressed as % maximum for an individual vascular bed, the pulmonary C-R curve is to the left of that of the hind limb. However, pressure (not shown), resistance and changes in resistance are always much greater in the hind limb. These results do not support a role for increased sensitivity of the pulmonary bed to circulating NE in the pathogenesis of persistent transient circulation.
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Green, R., Sheridan, R., Leffler, C. et al. 370 NOREPINEPHRINE (NE) CONCENTRATION-RESPONSE (C-R) RELATIONSHIPS IN KREBS-PERFUSED NEONATAL LAMB LUNG AND HIND LIMB. Pediatr Res 19, 172 (1985). https://doi.org/10.1203/00006450-198504000-00400
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DOI: https://doi.org/10.1203/00006450-198504000-00400