Abstract
The factors that affect production of fetal tracheal fluid have not been completely elucidated. We studied 14 chronically catheterized fetal sheep (120-130 days) to determine if bilateral sections of the carotid sinus and vagus nerves affect production of tracheal fluid. Each fetus had ligation of the trachea and cannulation with a catheter (100 cm long, 1.5 mm I.D.) that diverted all tracheal fluid into a soft intrauterine bag. A loop of catheter was exteriorized to permit collection of fluid from the lungs and bag. Fluid was collected once daily for 6 days after surgery. Seven fetuses had bilateral sections of the carotid sinus and vagus nerves; 7 had sham operations, all fetuses had similar arterial blood gas tensions, pH and mean blood pressures and low voltage electrocortical activity. The incidence of fetal breathing movements was lower in the denervated fetuses; however the production of tracheal fluid was not significantly different except for POD# 1 (table).
(Values are meanĀ±;SD; POD=post operative day; p<0.05) We conclude that denervation of peripheral chemoreceptors and lung receptors with afferent nerves in the vagus nerve does not affect production of tracheal fluid in fetal sheep.(USPHSHL27356)
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Murai, D., Waller, L., Lee, C. et al. 290 DENERVATION OF PERIPHERAL OSMORECEPTORS AND LUNG RECEPTORS DOES NOT AFFECT PRODUCTION OF TRACHEAL FLUID IN FETAL SHEEP. Pediatr Res 19, 159 (1985). https://doi.org/10.1203/00006450-198504000-00320
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DOI: https://doi.org/10.1203/00006450-198504000-00320