Abstract
Postnatally administered asphyctic insults to newborn rats has had an effect on growth & development compared to controls (Growth, 1984, 48, 120-133). Older literature suggests that adult female rats are more resistant to asphyctic episodes. To test this in RS, data were collected from 22 male asphyctic(MA) (day 1: X wt. 7.4±6gm) & 24 female asphyctic(FA) (day 1: X wt. 6.8±.5gm) RS. The asphyctic process was carried out in single fixed volume 22 ml. airtight capped jars & the outcome measure was the time interval to reach 30″ apnea. ANCOVA was done (regressing time to reach 30″ apnea on wt. for same day of life) to detect sex-specific time difference in day & wt.-adjusted pups.
Results: (See Table) 1) the mean unadjusted time interval to reach 30″ apnea was higher for females than males(all days NS)** 2) by ANCOVA, the mean wt. adjusted time interval to reach 30″ apnea were greater** in males for all days. The resistance to asphyxia seen in adult female rats could not be shown in asphyctic RS.
*mean time in minutes
**p > .05 (NS)
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Atakent, Y., Ferrara, A., Shukla, H. et al. 232 SEX SPECIFIC DIFFERENCES IN RESPIRATORY TOLERANCE IN RAT SUCKLINGS (RS) UNDERGOING ASPHYCTIC EPISODES. Pediatr Res 19, 149 (1985). https://doi.org/10.1203/00006450-198504000-00262
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DOI: https://doi.org/10.1203/00006450-198504000-00262