Abstract
Peviously we have demonstrated myocardial dysfunction in experimental group B streptococcal shock. To determine if myocardial dysfunction occurs in other forms of experimental septic shock, rabbits were instrumented to measure mean arterial pressure (MAP), heart rate (HR), left ventricular dP/dt (LVdP/dt) and end diastolic pressure (LVEDP), cardiac output (CO), pulmonary artery pressure (PAP), and arterial blood gases. Hemodynamic variables and blood gases were assessed before and 30 minutes after infusion of heat-killed S. epidermis (SE), H. influenza (HI) and E.coli (EC), 1012 organisms/kg. The Table shows mean values ± SEM for MAP and LVdP/dt for each group of animals at BASE and 30 minutes. * = different from BASE (p<.05).
MAP, LVdP/dt, CO, and HR all fell significantly in each experimental group and PAP rose significantly with EC and SE and was increased with HI. LVEDP was not altered significantly in any group. We conclude that septic myocardial dysfunction is not unique to a specific organism, but is a common component of both gram negative and gram positive septic shock. These data support the concept that endogenous substances modulate septic shock.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Peevy, K., Reed, T., Chartrand, S. et al. 202 COMPARISON OF MYOCARDIAL DYSFUNCTION IN THREE FORMS OF EXPERIMENTAL SEPTIC SHOCK. Pediatr Res 19, 144 (1985). https://doi.org/10.1203/00006450-198504000-00232
Issue Date:
DOI: https://doi.org/10.1203/00006450-198504000-00232