Abstract
The effect of hypothermia on respiratory failure has not been studied. One possible advantage of hypothermia in respiratory failure is the reduction of cardiac output, which may in turn lower intrapulmonary shunting. We measured venous admixture and other cardiorespiratory variables in 5 anesthetized adult dogs before and after surface cooling to 30°C, and again after isovolemic hemodilution with Dextran 75. Arterial blood gases and hemoglobin saturations were corrected for temperature. Cardiac output was calculated from oxygen consumption, which was measured directly using a closed circuit method. Caridorespiratory variables measured at baseline (38°C), during hypothermia (30°C) and during hypothermia and hemodilution (30°C+H) are shown in the table below. (x ± SEM, *p<.05) Venous admixture fell dramatically in 4 out of 5 dogs (from .24 ± .05 to /08 ± .02, x SEM, p<.Ol).
Hypothermia decreases intrapulmonary shunt in dogs and may be useful in patients with respiratory failure.
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Hershenson, M., Schena, J., Crone, R. et al. 187 HYPOTHERMIA DECREASES INTRAPULMONARY SHUNT IN DOGS. Pediatr Res 19, 142 (1985). https://doi.org/10.1203/00006450-198504000-00217
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DOI: https://doi.org/10.1203/00006450-198504000-00217