Abstract
A total of 163 children with typhoid fever were treated with co-trimoxazole (sulfamethoxazole 50 mg/kg per day, trimethoprim 10 mg/kg per day divided into two daily doses) for 14 days. The diagnosis was confirmed by positive blood or stool cultures and/or by the titer of agglutinins. All patients had a favourable clinical response; fever disappeared between the 3rd and 5th day of therapy (average 5.1 days). Subjective improvement also occurred in a short period of time. When the temperature curve of these cases was compared to that from 100 cases treated with chloramphanicol (fever disappeared on an average of 7.4 days), co-trimoxazole seems to be a more effective antimicrobial agent. Recently, eight patients with typhoid fever were given trimethoprim alone (10 mg/kg per day) and we obtained similar good results that with the use of co-trimoxazole (fever disappeared on an average of 4.8 days)
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Llorens-Terol, J., Martinez-Roig, A., Mur, A. et al. ALTERNATIVE THERAPY OF TYPHOID FEVER IN CHILDREN. Pediatr Res 19, 1107 (1985). https://doi.org/10.1203/00006450-198510000-00226
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DOI: https://doi.org/10.1203/00006450-198510000-00226